ADaM v2.1 explains the purpose of ADaM and how it can be used to support efficient generation, replication, and review of analysis results. The document describes fundamental principles that apply to all analysis datasets, with the driving principle being that the design of analysis datasets and associated metadata facilitate explicit communication of the content of, input to, and purpose of, submitted analysis datasets. It also describes ADaM metadata, the subject-level analysis dataset (ADSL) and the Basic Data Structure (BDS). Downloading ADaM v2.1 includes a one-page document titled "Important Considerations When Using ADaM v2.1".

ARM v1.0 for Define-XML v2.0 supports the submission of Analysis Results Metadata (ARM) as defined in ADaM v2.1.