| The Biomedical
Research Integrated Domain Group (BRIDG)
Model is a domain
analysis model representing protocol-driven
biomedical/clinical research. It was developed
to provide an overarching model that could
readily be understood by domain experts
and would provide the basis for harmonization
among standards within the clinical research
domain and between biomedical/clinical research
and healthcare.
Three important streams of development
have been brought together into this collaborative
framework:
- CDISC – In 2003, CDISC started
constructing a Domain Analysis Model
to support harmonization of their models
as well as with HL7.
- NCI – In 2004, the NCI's caBIG
initiative joined the CDISC BRIDG efforts
to construct a structured protocol representation
and to achieve interoperability among
clinical trials research in cancer
- In early 2005, the BRIDG model was
been adopted by the HL7 RCRIM Technical
Committee as the RCRIM Domain Analysis
Model and is being implemented at NCI.
The model emerged from an unprecedented
collaborative effort among clinical trial
experts from CDISC, the
US National Institutes of Health (NIH)/National
Cancer Institute (NCI), the Food
and Drug Administration (FDA),
Health Level Seven (HL7),
and other volunteers. The modeling effort
is using the HL7 Development Framework
(HDF).
This structured information model is
being used to support development of data
interchange standards and technology solutions
that will enable harmonization between
the biomedical/clinical research and healthcare
arenas.
The BRIDG Model serves to bridge standards,
as well as organizations and various communities,
including academic research institutions
and pharmaceutical product development
organizations and related service and
technology providers. It is also bridging
the gap between clinical research and
healthcare.
The model is represented in the Unified
Modeling Language (UML) using a software
tool called Enterprise Architect. A software
package named SubVersion is used for model
version control.
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